US President Barack Obama will meet the Prime Minister on Monday ahead of the G8 summit in Northern Ireland.
He will also hold bilateral talks with Russian President Vladimir Putin on Monday evening.
The Syrian conflict has been high on the world leaders' agenda, and David Cameron has said there is credible evidence that Syrian President Bashar al-Assad's regime has used chemical weapons in "multiple attacks".
The White House said: "The summit and related meetings will provide the President and his fellow world leaders an opportunity to address pressing economic, political and security challenges around the globe".
The President and family will arrive in Belfast on Monday morning, where he will deliver remarks at a event to highlight the "hard work, dialogue, and institutional development" the people of Northern Ireland have undertaken to advance peace and prosperity.
US President Barack Obama has tip-toed over the 'red-line' and armed Syrian rebels but it is a gamble of huge proportions.
Writing for ITV News, international affairs analyst David Butter looks at the timing of US support for Syria and when it may arrive.
Are the US supplied assault rifles too little, too late and what incentive is there for Assad to enter peace talks?