Scotland Yard has confirmed that Kate and Gerry McCann are not among the 38 people identified as "persons of interest".
The group that the McCanns were dining with in Praia da Luz on the night Madeleine went missing, are also not among the 38 people of interest.
Police believe Madeleine could still be alive, and they have drawn up a list of 38 people - 12 of them British - who they want to speak to.
What happened to Madeleine? It is likely only one person knows the answer, and finding that person is the focus of a British investigation.
The Met Police said there are 38 people of interest in the Madeleine McCann case. Here is a timeline of the key events in her disappearance.