The majors unit at Queen Elizabeth Hospital A&E has received 33 ambulances since midnight.
Most common among the ambulance complaints are chest pain and shortness of breath.
The unit is yet to receive a major trauma - a big road traffic accident, for example - on this shift.
A&E departments across the country are having what some people call "a challenging" time and others say is a full-blown crisis.
Queen Elizabeth Hospital Birmingham is a major trauma centre treating the most severely injured casualties from across the Midlands.