The Save Trafford General campaign said the closure of its A&E department is "tearing the heart out of the hospital".
Matthew Finnegan, the campaign's chairman, said the future of the hospital - widely considered to be the birthplace of the NHS - is now "in real danger".
Mr Finnegan said: "These decisions can't just be made by clinicians - they have got to listen to what local people say. And people want an A&E, it's not an unreasonable request.
"Local people will be appalled and disgusted that they have not been listened to."
More top news
Bodies are being buried in backyards and overwhelming morgues as officials try to find another plot of land to lay them to rest.
Authorities have warned that the death toll is likely to rise as much of the building is yet to be searched.
The PM will sound out the possibility of new free trade agreements with Gulf states for once the UK has left the EU.