The Save Trafford General campaign said the closure of its A&E department is "tearing the heart out of the hospital".
Matthew Finnegan, the campaign's chairman, said the future of the hospital - widely considered to be the birthplace of the NHS - is now "in real danger".
Mr Finnegan said: "These decisions can't just be made by clinicians - they have got to listen to what local people say. And people want an A&E, it's not an unreasonable request.
"Local people will be appalled and disgusted that they have not been listened to."
More top news
John Hesp, 64, took the poker world by storm by making it into the last seven of the competition.
Many parts of the UK seeing rain to start the weekend.
Can you guess what film the cow was trying to watch?