Health Secretary Jeremy Hunt said closing the accident and emergency unit at Trafford General Hospital is "necessary to provide safe and sustainable healthcare in the North West".
Campaigners have fiercely opposed the closure of the A&E unit at the hospital in Manchester, which is widely regarded as the birthplace of the NHS.
Following a review of the plan by the Independent Reconfiguration Panel, Mr Hunt told MPs that the closure can go ahead - provided that nearby A&E departments consistently meet national waiting time targets.
More top news
Harvey Proctor spoke out after police investigating allegations of historical child sex abuse searched his home.
More than a 100 doors have cropped up at the base of the woodland - but managers say they are threatening the enchanted forest.
Jonny Evans and Papiss Cissé are facing likely bans from the FA after appearing to spit at each other during a Premier League game