Health Secretary Jeremy Hunt said closing the accident and emergency unit at Trafford General Hospital is "necessary to provide safe and sustainable healthcare in the North West".
Campaigners have fiercely opposed the closure of the A&E unit at the hospital in Manchester, which is widely regarded as the birthplace of the NHS.
Following a review of the plan by the Independent Reconfiguration Panel, Mr Hunt told MPs that the closure can go ahead - provided that nearby A&E departments consistently meet national waiting time targets.
More top news
Police found one child chained to the ground, another tied to a door with a dog lead, while six others were also rescued.
Wintry scenes across the UK this late in April have not been seen since the mid-1980s.
The Labour leader will also announce an inquiry into anti-semitism and other forms of racism to be chaired by Shami Chakrabarti.