The first glimpse of the future King will make the front pages of newspapers around the world.
Royal photographer Arthur Edwards will be one of the many outside the Lindo Wing of St. Mary's Hospital to capture that moment.
Mr Edwards was there to snap Prince William when he emerged in his father's arms in June 1982.
ITV News' Paul Davies reports:
ITV News' Business Editor, Laura Kuenssberg, looks at how the royal baby could provide a much needed boost to the economy.
As news of the royal birth is celebrated around the globe a flood of souvenirs and memorabilia will go on sale to mark the occasion.
In London and around the world politicians, celebrities and members of the public have been celebrating the news of the royal birth.