The Public Health England figures, released ahead of World Hepatitis Day on Sunday, show that hospital admissions for end stage liver disease and liver cancer caused by hepatitis C increased from 574 in 1998 to 2,266 in 2012.
The World Health Organisation (WHO) has called hepatitis a "silent epidemic" because so many people do not realise they are infected.
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The chief medical officer for England told ITV News that misuse of antibiotics must be curbed, and new ones must be developed.
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