The Public Health England figures, released ahead of World Hepatitis Day on Sunday, show that hospital admissions for end stage liver disease and liver cancer caused by hepatitis C increased from 574 in 1998 to 2,266 in 2012.
The World Health Organisation (WHO) has called hepatitis a "silent epidemic" because so many people do not realise they are infected.
More top news
The Spaniard has overseen 10 straight victories since taking charge at the Etihad Stadium, including a derby win over Manchester United.
Mary Berry has "absolutely no plans to retire", despite reports she only intends to work for another year, her agent has said.
China has started searching for extraterrestrial life with the 'world's largest telescope' which measures half a kilometre in diameter.