The Public Health England figures, released ahead of World Hepatitis Day on Sunday, show that hospital admissions for end stage liver disease and liver cancer caused by hepatitis C increased from 574 in 1998 to 2,266 in 2012.
The World Health Organisation (WHO) has called hepatitis a "silent epidemic" because so many people do not realise they are infected.
More top news
More wet weather but feeling mild and muggy
European court says US-EU treaty allowing transfer of personal data by US companies is invalid due to privacy fears.
Luxury car maker Lexus has made a full-size driveable 'Origami car' out of cardboard to celebrate the craftsmanship of their workers.