The Public Health England figures, released ahead of World Hepatitis Day on Sunday, show that hospital admissions for end stage liver disease and liver cancer caused by hepatitis C increased from 574 in 1998 to 2,266 in 2012.
The World Health Organisation (WHO) has called hepatitis a "silent epidemic" because so many people do not realise they are infected.
More top news
A Belgian man convicted of murder and rape will be allowed to let doctors end his life following a controversial ruling.
A great-grandmother who completed a skydive to raise money for the hospice which cared for her husband has vowed to do it again at 90.
Urban Outfitters has apologised for a 'red-stained' sweater bearing the logo of a US university where four students were shot dead in 1970.