Paul Lamb has told ITV News he will "never give up" his legal battle for the right to die.
He says he "had little hope" of a ruling in his favour, but is ready to appeal again to the Supreme Court.
"The judge said he had 'sympathy' for me," Mr Lamb said. "I hate that word. Sympathy is no good to me. When he talked about sympathy I just wanted to shout at him.
"If they had a dog that was in the same pain as I am, they wouldn't allow it. The law is just cruel," he added. "There are thousands of people like me, and all we want is the individual right to choose how to end our lives."
Locked-in syndrome sufferer Tony Nicklinson's widow and a paralysed victim have pledged to continue to challenge right-to-die law.
Locked-in syndrome sufferer Tony Nicklinson campaigned for years to win the right to end his life. Here is the timeline of his struggle.