Changing the culture of the NHS will "trump" any new rules and strategies, Professor Don Berwick's review said.
Improving patient safety should "permeate every action and level in the NHS", the report added.
The Government-ordered report said "achieving a vastly safer NHS will depend far more on major cultural change than on a new regulatory regime".
More top news
Tom Bradby will play host to the leaders of the three main parties, as well as the biggest names from the worlds of arts and culture.
One of the greatest sporting events on earth gets underway this week as the Ryder Cup heads to Scotland, here's everything you need to know
A toddler was in need of an unusual rescue after she got a kettle stuck on her head while playing at home in Chile.