As many as one in 40 babies is born with a birth defect in England and Wales, according to the most comprehensive study of the issue to date.
The most common anomalies are congenital heart defects, which affect at least six in every 1,000 babies.
Those suffering heart problems can require major surgery, and around 6 percent of babies with a heart defect die before their first birthday.
The report, by researchers at Queen Mary University of London in conjunction with theBritish Isles Network of Congenital Anomaly Registers, collated data from six regional registers, giving a national coverage of 36% of all births.
Researchers then provided estimates to flesh out the other regions of England and Wales.
More top news
More than £12,000 has been raised for a frail and visually impaired pensioner who was attacked near his home.
A search is underway for a missing 10-year-old who was last seen throwing snowballs with friends in Ashton-under-Lyne, Greater Manchester.
Jihadis turn to groups like IS because they're 'not making it with girls so turn to other forms of spiritual comfort', Boris Johnson claims