As many as one in 40 babies is born with a birth defect in England and Wales, according to the most comprehensive study of the issue to date.
The most common anomalies are congenital heart defects, which affect at least six in every 1,000 babies.
Those suffering heart problems can require major surgery, and around 6 percent of babies with a heart defect die before their first birthday.
The report, by researchers at Queen Mary University of London in conjunction with theBritish Isles Network of Congenital Anomaly Registers, collated data from six regional registers, giving a national coverage of 36% of all births.
Researchers then provided estimates to flesh out the other regions of England and Wales.
More top news
Food imports to the war-ravaged country are at an all time low and its people are at risk of catastrophic hunger, according to the charity.
A "life-size" baby Jesus has been found by police after the doll was stolen from its crib in a church nativity scene.
A man who has been on the run from the FBI for 10 years has been jailed for sexually assaulting a teenage girl in a Lancashire park.