Gill Mulhall, the current headteacher of the school Daniel Pelka attended, said if his teachers had been aware of his suffering then they would have "acted very differently".
Ms Mulhall said: "What was proven in the criminal trial is that his mother was a convincing manipulator who fooled many professional bodies over a long period of time by producing a convincing act as a caring parent.
"If we had been aware of the bigger picture of Daniel's life, or had any doubts about his mother, then we would of course have acted very differently.
"What we want to see now are changes where schools are aware of concerns from other agencies which affect our pupils to try and ensure that nothing can ever happen again."
Opportunities to protect Daniel Pelka, who was beaten to death by his mother and stepfather, 'were missed' a serious case has revealed.
Daniel Pelka's Serious Case Review is strong on what went wrong, but weak on explaining why it was allowed to happen.