Ottawa Fire Services spokesman Marc Messier told CTV News the initial estimate was that five people have been killed.
He later told CBC News that six or more others have been taken to hospital with serious injuries.
VIA Rail, which operates the national passenger service in Canada, confirmed the crash and said there were no major injuries reported on the train.
More top news
James Deen, one of the world's most famous porn stars, denies allegations of sexual abuse made by several women, including former partners.
The Good Morning Britain team have been showing support for Text Santa by performing their own version of the Wham! hit Last Christmas.
A seven-month-old baby was shot and killed when a shotgun belonging to his mother's boyfriend went off in their living room, police say.