Ottawa Fire Services spokesman Marc Messier told CTV News the initial estimate was that five people have been killed.
He later told CBC News that six or more others have been taken to hospital with serious injuries.
VIA Rail, which operates the national passenger service in Canada, confirmed the crash and said there were no major injuries reported on the train.
More top news
A Cornish village fundraising to develop a community centre were helped out with a donation from an unlikely source - the Emir of Dubai.
Thursday will be an unsettled day across many northern areas with outbreaks of rain which could be heavy, accompanied by strong winds.
Apple has marked the 10th anniversary since the first iPhone went on sale.