Nick Bonnie, 30, collapsed at a nightclub in Manchester in the early hours of Saturday.
Mr Cameron said: "This is a tragic death. We've seen too many of these".
When asked if the Government has a grip on its drugs policy, he said: "The focus of Government has quite rightly been on education...and treatment".
He added that he disagreed with the Chief Constable of Durham's call for some drugs to be decriminalised as "it would make them more available and lead to more problems".
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A Met Office warning covering much of England and south-east Wales is expected to remain in place until 11am.
A band of cloud and patchy rain is expected across Scotland and Northern Ireland, moving southeast as the day progresses.