Kate and Gerry McCann are to make a significant television appeal in light of "fresh, substantive" material unearthed as part of a British police investigation into their daughter's disappearance.
The McCanns will appear live in the studio during an episode of BBC Crimewatch on Monday October 14, which will also feature a reconstruction and pre-recorded interviews with the couple.
Scotland Yard is for the first time trawling through a vast log of mobile phone traffic identified in Praia da Luz, in Portugal, at the time of Madeleine's disappearance.
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The man, in his thirties, was found with stab injuries on the upper deck of a bus in Handsworth, Birmingham, on Monday night.
Thousands of passengers now face delays, with Southeastern trains warning "all services" would be affected.
Paramedics attended a scene in Willesden, north-west London, on Monday afternoon where they found the teenager with stab wounds.