The senior investigating officer into Madeleine McCann's disappearance has said he hopes the forthcoming appeal will prompt new witnesses to come forward.
Metropolitan Police's Detective Chief Inspector Andy Redwood said: "We now believe we have the most complete picture to date of the events surrounding her disappearance.
"We are now making targeted and new appeals for help from the public.
"I truly believe there are people out there who hold the key to Madeleine's disappearance, and that so far they may be completely unaware of that fact."
More top news
A senior health official has called for vitamin supplements for children amid warnings over a rickets 'epidemic'.
The former Top Gear also revealed his cancer scare just two days before the fracas which led to his sacking.
Tonight will start off clear in many areas, but cloud will increase from the east overnight, bringing some light and patchy rain.