A BBC Crimewatch reconstruction of Madeleine McCann's disappearance will star a three-year-old actress as Maddie.
A small production team from the programme have spent a week filming abroad for the new appeal, which goes to air on Monday 14th October.
Crimewatch presenter Kirsty Young speaks to the McCanns in the new programme, while presenter Matthew Amroliwala has been to Praia da Luz in Portugal to explore the new focus of the police investigation.
The McCanns and the senior investigating police officer will also be live in the studio.
More top news
In her message Theresa May praised the "inspirational bravery" and "unbreakable spirit" of Mancunians in the wake of the blast.
ITV News has obtained exclusive footage of the moment armed police raided a house believed to be linked to the Manchester suicide bomber.
The Manchester Evening News set up a JustGiving page asking people to support the families of those affected by the suicide bombing.