German television station ZDF will stage a reconstruction of the events of the night of May 3, 2007 when Madeleine McCann disappeared from the room in which she was sleeping in Prais de Luz.
The fresh appeal follow's last night's Crimewatch appeal for new witnesses to come forward.
A special edition of the crime programme Aktenzeichen XY - Ungeloest which is translated as "File XY - Unsolved", will be aired on Wednesday night and will feature an appeal for information from Kate and Gerry McCann.
Detectives have ruled out the key sighting that underpinned the original Madeleine McCann investigation and adopted a new focus in the hunt.
On the day she disappeared Madeleine McCann asked her parents a question: “Why didn’t you come when Sean and I cried last night?”
Latest appeal is the parents' best - and most likely their last - hope to find out through police work what happened to their daughter.