Gerry and Kate McCann have said they are "absolutely delighted with the overwhelming public response" to a BBC Crimewatch appeal, which was broadcast last night.
“We know that the public desperately want to help the search for Madeleine," they said in a statement.
"We are genuinely hopeful that one or more of these responses will lead to a major breakthrough in the investigation.
They added: "If anyone was in Praia da Luz around the time of Madeleine’s abduction and has not spoken to the Metropolitan Police, or if they know who any of the e-fits might be, please have the courage to come forward and speak to the police in confidence.”
Detectives have ruled out the key sighting that underpinned the original Madeleine McCann investigation and adopted a new focus in the hunt.
On the day she disappeared Madeleine McCann asked her parents a question: “Why didn’t you come when Sean and I cried last night?”
Latest appeal is the parents' best - and most likely their last - hope to find out through police work what happened to their daughter.