Scotland's First Minister Alex Salmond has said he is "not accepting that we are going to have a closure" at the Grangemouth facility.
"I am not prepared to give up on Grangemouth and I don't think anyone else should be either," he told BBC News.
Mr Salmond said that Ineos' management and the union were "inches away" from an agreement, which ultimately failed because of "nuances in the wording".
He called for a final effort to bring the two sides together.
Grangemouth owners Ineos are in last ditch talks with the workers' union, but the workforce is just one of the problems facing the plant.
Thousands of jobs are under threat after a dispute over conditions led to a shock decision to close the petrochemical site in Grangemouth.