Officers have said that they will travel regularly to Portugal as part of the UK investigation, following a meeting with Portuguese police, the Met Police said in a statement.
Assistance Commander Mark Rowley, specialist crime and operations, said: "The meeting was very positive, and we and the Policia Judiciara have a shared determination to do everything possible to discover what happened to Madeleine.
"Colleagues in Portugal fully shared with us the developments in their review, and the fact that they were taking the significant step of applying for the investigation to be formally reopened.
"From the near future, MPS detectives from Operation Grange will travel regularly to Portugal under the terms of the ILOR in relation to the UK investigation."
More top news
Tina Green is to be called before the Work and Pensions Committee as it looks into how the high street chain went into administration.
The Boeing 777 was reportedly intercepted by two Hungarian Air Force Gripens after it lost contact with air traffic controllers.
Culture Secretary is mulling over a bar on the broadcaster going head-to-head with commercial rivals as part of the review of its charter.