The new search of the house where Claudia Lawrence lived alone in Heworth Road, York, follows the formation of a new Major Crime Unit at the North Yorkshire force.
But senior detectives stressed the move has not been prompted by any new lead.
Detective Superintendant Dai Malyn, who heads the Major Crime Unit, said: "There's no new smoking gun or startling piece of evidence. I wouldn't want people to believe that's the case. This is just part of the review process."
Mr Malyn said the search, which could last a fortnight, was the beginning of a review as part of the new team's remit to look at important cold cases.
He said: "Most cold case review work considers forensic re-evaluation as techniques advance and this case is no different."
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The boy was found unconscious and in cardiac arrest and was rushed to hospital where he died.
The victim, who was wearing her uniform at the time, was found knocking on doors nearly four hours after she was abducted.
There will be gales across Scotland and northern England this morning, but these will gradually ease through the afternoon.