He is expected to say: "Britain is in a global race for jobs and wealth. Our infrastructure is decades out of date and we urgently need to invest and build.
The Prime Minister has tasked the new boss of HS2 with cutting costs, amid criticism from Labour that the project has a "black cheque".
The Prime Minister accused delayers of "betraying" those in the north who are most likely to benefit from the high-speed rail project.
"Those who want to delay or obstruct HS2 show a lack of vision. They are playing politics with Britain's prosperity. They are betraying everyone north of Watford. And they want to condemn Britain to the slow lane.
"We can either tell our grandchildren we made big, long-term decisions to build a better country... Or we can tell them we dithered for decades while the world raced ahead.
More top news
A few showers are expected across the west of Scotland tomorrow but elsewhere high pressure remains in control.
Footage posted to YouTube shows the moving moment a nine-week-old boy hears his mother speak to him for the first time.
The tribute song features in the latest installment of the film franchise, and climbed 21 places to claim the top spot this week.