More than 20 people died and another 20 injured when a train crashed into a pickup truck and a minibus near Cairo, the state news agency MENA said.
The train, coming from Aswan and passing through Bani Swaif, crashed at a crossing near the Giza district, reports said.
The incident could spark protests by the Egyptian public who have long complained that successive governments have failed to enforce even basic safeguards, leading to a string of deadly crashes.
"We are still investigating the incident and once we are done we will issue a statement," an Interior Ministry source told Reuters.
More top news
The Metropolitan Police is to pay over £400,000 in compensation to a woman who had a child with an undercover officer.
Local councils want ban on term time holidays scrapped because it is too rigid.
It will be a wet start tomorrow for many but things are looking up for the afternoon.