More than 20 people died and another 20 injured when a train crashed into a pickup truck and a minibus near Cairo, the state news agency MENA said.
The train, coming from Aswan and passing through Bani Swaif, crashed at a crossing near the Giza district, reports said.
The incident could spark protests by the Egyptian public who have long complained that successive governments have failed to enforce even basic safeguards, leading to a string of deadly crashes.
"We are still investigating the incident and once we are done we will issue a statement," an Interior Ministry source told Reuters.
More top news
Simon Cowell says he "felt like a bit of an idiot" after learning the Britain's Got Talent winner used a stunt double dog during the final.
An advert for luxury fashion brand Yves Saint Laurent has been banned for featuring a model with a visible rib cage and stick-thin legs.
Every school rated as inadequate by Ofsted will be turned into academies under new laws, the Education Secretary has announced.