More than 20 people died and another 20 injured when a train crashed into a pickup truck and a minibus near Cairo, the state news agency MENA said.
The train, coming from Aswan and passing through Bani Swaif, crashed at a crossing near the Giza district, reports said.
The incident could spark protests by the Egyptian public who have long complained that successive governments have failed to enforce even basic safeguards, leading to a string of deadly crashes.
"We are still investigating the incident and once we are done we will issue a statement," an Interior Ministry source told Reuters.
More top news
Crisis talks are to be held on the future of curry houses as cheap supermarket deals and immigration rules threaten the £4 billion industry.
Rain expected in the next 24 hours - no surprise there with it being a Bank Holiday - but there'll also be some brighter skies in places.
The presenter's former bandmate failed to impress the judges with his rendition of OneRepublic's Counting Stars.