More than 20 people died and another 20 injured when a train crashed into a pickup truck and a minibus near Cairo, the state news agency MENA said.
The train, coming from Aswan and passing through Bani Swaif, crashed at a crossing near the Giza district, reports said.
The incident could spark protests by the Egyptian public who have long complained that successive governments have failed to enforce even basic safeguards, leading to a string of deadly crashes.
"We are still investigating the incident and once we are done we will issue a statement," an Interior Ministry source told Reuters.
More top news
A Scottish teenager has become the first person in the UK to pass his driving test – using a sat nav.
Khaled Hosseini, author of the Kite Runner, and UNHCR Goodwill Ambassador visits Syrian refugee camps in Jordan.
Graham Taylor has refuted claims he was asked by the FA to limit the number of black players he selected when England boss.