Dr Conrad Murray feels "very sorry that Michael is dead" and described it as "a loss I will never recover from", in an interview with Daybreak.
However, he maintained his innocence and described himself as "an innocent man who has been persecuted to the maximum, sent to jail and demoralised".
Dr Murray, who was found guilty of Michael Jackson's involuntary manslaughter in 2011, expressed his condolences over the lives of the three children the pop star left behind:
"I am very very sad about Michael's children. There is no doubt about that.
"I remember Paris telling me she didn't want to be an orphan," he said.