The United Nations' first relief airlift to Syria from Iraq will deliver food and winter supplies to the mostly Kurdish northeast.
The UN has got the permission of both governments, the UNHCR refugee agency said.
Syria gave permission about two weeks ago for the cross-border U.N. operation from Iraq into Syrian Kurdish areas of Hassakeh province.
The airbridge will begin on Thursday. Up to 12 flights are scheduled through Sunday, said Amin Awad, director of UNHCR's Middle East and North Africa Bureau.
U.N. agencies have ferried limited aid supplies into Syria from Iraq and Lebanon, but not via Turkey because of objections from President Bashar al-Assad's government.