A British Airways plane bound for London clipped its wing on a nearby building as it was preparing to take off from Johannesburg on Sunday, South Africa's airports authority said.
The Boeing 747-400 carrying about 180 passengers was taxiing on the runway at O.R. Tambo International when its wing hit the building.
No one on the plane was hurt, but four ground employees who were in the building sustained minor injuries, the Airports Company South Africa (ACSA) said, adding that an investigation was underway.
Photos posted on social media site Twitter showed a brick building with what appeared to be an aircraft wing lodged in its top floor.
More top news
Local authorities say the current system of Traffic Regulation Orders are time-consuming, expensive and bureaucratic.
A recording of the actor's apology to air traffic control has been released after he mistakenly landed his plane on a taxiway last month.
New travel report looks at best value European city break destinations for UK tourists.