Long-term unemployed youngsters are twice as likely as their peers to have been prescribed anti-depressants, researchers have found.
A study from the Prince's Trust revealed 16 to 25-year-olds who have been out of work for at least one year were more likely to self-harm and contemplate suicide.
Out of the 2,000 young adults quizzed by the youth charity, those unemployed for over a year were more likely to say they had no-one to confide in.
Martina Milburn, chief executive of The Prince's Trust, said: "More than 440,000 young people are facing long-term unemployment, and it is these young people that urgently need our help.
"If we fail to act, there is a real danger that these young people will become hopeless, as well as jobless."
More top news
The last day of the inquiry into Alexander Litvinenko's murder has heard that Vladimir Putin should be held responsible for his death.
American philanthropists have pledged to match new donations up to $100,000 to the research team who had been tracking Cecil since 2008.
The driver of a lorry that crashed killing six people had "satisfactory" references from his previous employer despite a written warning.