The first pint has been bought at the Hope and Champion, a Wetherspoons pub located at the M40 services in Beaconsfield.
The controversial pub is Britain's first at a motorway service station, and will be open from 4am to 1am seven days a week.
More top news
Weight of people trying to sign caused government petition to website to crash as Europhiles try to force a rerun of the EU vote.
A mother whose young daughter died after allegedly "shooting herself in the face" has been charged with murder.
Hundreds hit the streets of some of England and Scotland's biggest cities in protest over the "anti-immigration" tone of the Brexit campaign