Two of the key components of the Prime Minister's European strategy are tonight in disarray.
The French President rebuffed him over the reform of the European Union.
And the vehicle for putting any such reforms to the British people - a referendum - was voted down in the House of Lords by Labour and the Liberal Democrats.
Mr Cameron says he will fight on, determined to find a way to hold a referendum. His political reputation may depend on it.
ITV News Political Correspondent Libby Wiener reports:
More top news
The Australian government said Russia's participation in the Rio 2016 Games risks damaging the reputation of the Olympic movement.
PM Malcolm Turnbull said people convicted of terrorism-related charges would be held indefinitely if they pose an ongoing threat to society.
Democratic National Committee chair Debbie Wasserman Schultz stands down after leaked emails show party actively favoured Hillary Clinton.