Two of the key components of the Prime Minister's European strategy are tonight in disarray.
The French President rebuffed him over the reform of the European Union.
And the vehicle for putting any such reforms to the British people - a referendum - was voted down in the House of Lords by Labour and the Liberal Democrats.
Mr Cameron says he will fight on, determined to find a way to hold a referendum. His political reputation may depend on it.
ITV News Political Correspondent Libby Wiener reports:
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This morning the prime minister spelled out her belief that we can thrive outside the single market.
"Important clarity" or the grounds for the "theft of democracy"? The PM's declared aims for negotiations have received a mixed response.
A divided theme across the UK today