The family of Philip Seymour Hoffman have said they are "devastated" by news of his death. In a statement, they said:
We are devastated by the loss of our beloved Phil and appreciate the outpouring of love and support we have received from everyone.
This is a tragic and sudden loss and we ask that you respect our privacy during this time of grieving. Please keep Phil in your thoughts and prayers.
A variation 100 time more potent than heroin - laced with the painkiller Fentanyl - is causing a spike in deaths on the US East Coast.
Philip Seymour Hoffman joins a sad list of Hollywood stars whose lives were seemingly cut short by drugs, here is a look at other losses.
A look at the life and career of Philip Seymour Hoffman who has died from an "apparent drug overdose" aged 46.