Prime Minister David Cameron said that Labour's win at the Wythenshawe and East Sale by-election was not "particularly surprising", but conceded that voters were sending a signal to the Conservative party, which came third in the vote, behind UKIP.
"Obviously one would prefer to come second rather than third, but I dont think this is a particularly surprsing result in Labour holding this seat," Mr Cameron told ITV's Daybreak.
"I don't think it was the sort of break through that people were talking about," he added.
"When people know that there's a by-election, they know the government isn't going to change, but obviously messages are sent, and signals are sent and protests are made, and governments should always listen to those things and I always do."
More top news
Tonight it'll become quite clear with a patchy frost in places. The breeze will keep much of the fog at bay.
He suggested people who are not concerned about the new notes donate their bodies for 'decorative use in future five pound notes'.
Tens of thousands of people lined the streets of Chapecó for a memorial ceremony honouring footballers killed in a plane crash.