The Royal Bank of Scotland has highlighted the "political risks" posed by Scottish independence to its business, saying it could "significantly" impact the group's credit ratings.
Comments in its annual results also questioned whether the move would affect Scotland's status in the European Union.
During 2013, the focus on the question of potential Scottish independence from the UK has heightened and the Scottish government will be holding a referendum in September 2014.
A vote in favour of Scottish independence would be likely to significantly impact the Group’s credit ratings and could also impact the fiscal, monetary, legal and regulatory landscape to which the Group is subject.
Were Scotland to become independent, it may also affect Scotland’s status in the EU.
More top news
Babies born at weekends in NHS hospitals are more likely to die in their first week than those delivered on weekdays, new research suggests.
A 16-year-old boy has died after an "altercation" between a group of men in Leicester.
The Chancellor will present his Autumn Statement and Spending Review to the House of Commons on Wednesday.