Jeremy Hunt has compared the Mid Staffs scandal to Chernobyl and the Bhopal gas disaster in an interview with ITV News Political Correspondent Libby Wiener.
The Health Secretary said the accidents - both of which killed thousands and left many more injured - were "turning points" for their industries.
He said he hoped Mid Staffs would mark a similar change in the NHS.
Asked if similar negligence extended across the system, Mr Hunt said front-line staff have warned that "Mid Staffs wasn't just something that happened in one hospital".
More top news
A woman called police in Minnesota to warn them of Prince's 'out of control' cocaine habit in 2011, according to police records.
Researchers say they believe they may have found Captain Cook's ship Endeavour - now the Lord Sandwich - in Rhode Island.
Republican frontrunner said Ted Cruz's father was with JFK's killer at the time of the assassination.