Barclays looks set to axe hundreds more jobs, mainly at its investment banking arm due to a strategic review that would be published on May 8.
The review is likely to mean hundreds of job cuts in addition to plans announced earlier this year by the bank to slash 12,000 posts.
Chief executive Antony Jenkins wrote to all group staff this morning, saying the company would answer questions including how best to "simplify" its operations and which of its businesses it should "focus on and invest in".
Mr Jenkins warned staff that regulation and the wider economy were having a "significant effect on some parts of our business which we need to address proactively".
He added: "The future for Barclays will be as a strong, focused, international bank. And the investment bank will continue to be part of that mix".