Chancellor George Osborne has said the Newark by-election win was a "strong win for the Conservatives" and it was "disastrous" for the Labour Party.
Asked what he thought of the Ukip performance after the anti-EU party came second, he said:
"The Ukip vote was down on where it was a few weeks ago. We have an argument we can take to the country now about the change Britain needs."
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The Prime Minister said Parliament will be given a binding vote on the final deal, but said the result will not stop Britain leaving the EU.
Officials from the train drivers' union Aslef will meet managers from Southern Railway, whilst the RMT will meet separately with Acas.
Last week the organisation wrote on Twitter: "If Obama grants Manning clemency Assange will agree to US extradition".