A single injection that slashes the risk of heart attacks by up to 90% could be available within 10 years, say scientists.
The jab, that only has to be administered once, has already been tested successfully on mice.
It uses cutting-edge DNA-editing technology to "knock out" a liver gene linked to raised levels of cholesterol in the bloodstream.
Dr Kiran Musunuru, from the Harvard Stem Cell Institute (HSCI), said: "You could think of this therapy as something like a vaccination.
"It could be a one-time treatment, a permanent alteration. If you used this in a population, you could reduce the occurrence of heart attack by 30%, 50%, 90%."