Twin teenage girls who are thought to have travelled to Syria are "deeply religious Muslims", police understand.
It is understood an older brother has joined the extremist militant group Islamic State of Iraq and the Levant (Isis), and one line of inquiry is that the girls may have flown out to join him.
The girls, from a large Somalian family, flew from Manchester International Airport to Turkey which borders Syria where the civil war involving Muslim militants is raging.
Greater Manchester Police said the pair had been in contact with relatives since their departure.
More top news
After the Indiana polls close, ITV News asked Ted Cruz supporters if they could back Donald Trump as the Republican presidential nominee.
With his massive victory in Indiana, Donald Trump can now not be stopped from becoming the Republican nominee.
Donald Trump is predicted to win the crucial Republican Indiana primary, US media have projected.