The NCA said suspects include doctors, teachers, Scout leaders, care workers and former police officers. In total, only 39 registered sex offenders are among those arrested.
Officers have searched 833 properties and examined 9,172 computers, phones and hard drives.
The NCA said it built up "intelligence packages" on suspects and sent them to police forces across Britain.
More top news
In Berwick-upon-Tweed - the town at the northern-most tip of England - history has taught them that no border necessarily lasts forever.
His car was about to get towed away. But he had other ideas.
Our experts take a look at the key issues that would face Scotland and the rest of the UK if Scots vote for independence.