The NCA said suspects include doctors, teachers, Scout leaders, care workers and former police officers. In total, only 39 registered sex offenders are among those arrested.
Officers have searched 833 properties and examined 9,172 computers, phones and hard drives.
The NCA said it built up "intelligence packages" on suspects and sent them to police forces across Britain.
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A Met Office warning covering much of England and south-east Wales is expected to remain in place until 11am.
A band of cloud and patchy rain is expected across Scotland and Northern Ireland, moving southeast as the day progresses.