The company behind a life-extending prostate cancer drug said they are "disappointed" by the decision not to extend its availability in NHS England.
Abiraterone will continue to be available only to those who have already undergone chemotherapy, Nice, the health service financial watchdog, ruled.
Dr Peter Barnes, medical director at Janssen, who manufacture the drug, said the decision will leave suffers no option but to accept chemotherapy "they may not necessarily need or want yet."
Nice said the drug is "not cost effective at its current price."
We are very disappointed with this decision which, if it stands, will leave thousands of men in England in the advanced stages of prostate cancer with no option but to accept chemotherapy - which they may not necessarily need or want yet - before being eligible to receive abiraterone routinely on the NHS.
These men will eventually be able to receive abiraterone on the NHS after chemotherapy anyway, but will be denied the option of taking it earlier on in their illness.
More top news
Nicola Sturgeon has attacked the "scale and speed" of the Conservatives' planned spending cuts in her first major post-election speech.
Mobile phone giant O2 has apologised after service suddenly went down in a number of areas across the UK, sparking a flood of complaints.
A grandma who became an online hit when her grandson started tweeting pictures of her balancing things on her head has gone viral - again.