Sir Michael Parkinson has told ITV News the investigation into his friend Sir Cliff Richard and others "feels like some sort of witch hunt."
He said anyone who has not been charged with a crime should not be named by police or have their names reported in the press.
The talk show host, who lives close to disgraced entertainer Rolf Harris, criticised police handling of such cases saying "the media were there before the police were."
He added there was a "lot to be learned" from Operation Yewtrew and said media should "tread more softly" when covering such stories.
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A 35-year-old and a 27-year-old man, both from the Birmingham area, have been arrested and remain in police custody.
Molly Owens, was reported missing on Friday and is believed to be with her father, who is wanted after failing to appear in court.
Former Diversity dancer Robert Anker has died in a car crash in Canada.