The British police police have requested that the French police put into effect their Child Rescue Alert System - a nationwide operation looking at CCTV and trying to pick up the vehicle registration of their car to try to find a location.
So the question is not if this family will be found, but when, given the urgency of the situation.
And when they are found, Ashya is clearly going to have to be taken to a hospital with the same specialist care that he was receiving at Southampton General.
Ashya King's parents told the Daily Mail they fled the UK after being told NHS treatments would leave him with life-long disabilities.
The head of the police force which applied for a European Arrest warrant against the parents of Ashya King has now urged their release.
A British mother whose son's life was saved by proton therapy has told ITV that she defied NHS doctors' advice to pursue the treatment.