The effects of using of e-cigarettes is stronger in adolescents than adults, experts claim.
Professor Eric Kandel, whose research suggests E-cigarettes could lead to harder drug use, said: "The effects we saw in adult mice are probably even stronger in adolescent animals.
"One drug alters the brain's circuitry in a way that enhances the effects of a subsequent drug. Therefore, we should do all we can to protect young people from the harmful effects of nicotine and the risks of progressing to illicit drugs."
More than a million people in the UK are believed to get their nicotine fix from e-cigarettes but opinion is divided about the safety of them.
The first E-cigarette dates back to 1963 in Pennsylvania when a 40-a-day smoker filed for a patent "smokeless non-tobacco cigarette".
More top news
The drugs are used to control both pain and inflammation, and are commonly taken by people with arthritis.
The veteran singer, 75, will release his 101st album - 'News of Just ... Fabulous Rock 'n' Roll' - in November.
The Duke and Duchess of Cambridge were left cautiously watching every step after making an impromptu visit aboard a steam train.