The 43 Tesco stores facing closure have not yet been made public but a "significant proportion" will be Tesco Express convenience stores at sites across the country.
New chief executive Dave Lewis has not yet indicated the scale of the job losses at the beleaguered supermarket, with full details set to be known by April.
Employees affected by the closures will be informed over "coming months".
Head office jobs will also see cuts as Tesco cuts overheads by 30%.
Mr Lewis said he understood how the announcement would hit "hard-working people", adding: "I am not immune to the impact of the decisions we have had to take on our colleagues."
Here is a look at retail giant Tesco's most significant setbacks over the past four years.
Tesco's CEO is promising shoppers bigger discounts and better service but there isn't much room to make aggressive cuts without self-harm.
The under-pressure supermarket is trying to regain market share by cutting prices on big brands such as Coca-Cola, Hovis and Marmite.