Head coach Antonio Conte is poised to rotate his players when Chelsea make their Champions League return on Tuesday night.
The Premier League winners play their second of seven games in September on Tuesday night when their Group C campaign opens against Azerbaijan's Qarabag.
Sunday's league clash with Arsenal follows before a midweek Carabao Cup tie with Nottingham Forest for the Blues, who won the Premier League in Conte's first season as boss.
The Italian said: "You are never relaxed in England, because you have to play a tough league and also FA Cup and also Carabao Cup.
"Now we are starting to play the Champions League. To play 60, 65 games it's normal, but it's not easy.
"In my past sometimes before a Champions League game you rested. In England it's not easy to do this.
"When you make the decision (on selection) there is always the risk. The risk could be to play with the same players as against Leicester and then after the game 'why didn't you change the team that was tired?'"
"I must be realistic, I must be calm, to make the best decision for these seven games."