Ireland captain Rory Best makes his first start of the season for Ulster, as first meets third in the Pro12 at the Kingspan.
Les Kiss makes eight changes to the team that triumphed over Glasgow at Scotstoun, as he looks to utilise his squad's strength going into a packed period of five games in four weeks.
Tommy Bowe is on the bench and could make his first appearance in five months against his former team, following his layoff with a knee injury.
Craig Gilroy is fit again and starts, while Charles Piutau reverts to fullback.
Injuries to Stuart McCloskey, Stuart Olding and Luke Marshall mean Jared Payne will start in midfield, alongside Darren Cave, who put in an impressive try-scoring performance against Glasgow.
Paul Marshall is given the nod over Ruan Pienaar at scrum half.
Ospreys, beaten last week by Leinster, make six changes.
Dan Evans returns at fullback and Bradley Davies joins international teammate Alun Wyn Jones in the second row, while Dan Baker plays at number eight.
Nicky Smith gets his 50th cap at loose-head prop, coming in for Paul James.
Ulster will be hoping to maintain their winning start to the Pro12 season, but face a tough task against the Ospreys, by a margin the league's most prolific points scorers. Just two points separates the sides.
Ulster: C Piutau, C Gilroy, J Payne, D Cave, L Ludik, P Jackson, P Marshall; : K McCall, R Best, R Ah You, A O'Connor, F van der Merwe (capt), I Henderson, S Reidy, R Wilson.
Replacements: J Andrew, C Black, R Kane, K Treadwell, R Diack, R Pienaar, B Herron, T Bowe.
Ospreys: D Evans, J Hassler, B John, J Matavesi, E Walker, D Biggar, R Webb; N Smith, S Parry, D Arhip, B Davies, A Wyn Jones (capt), J King, J Tipuric, D Baker.
Replacements: S Baldwin, P James, M Fia, R Thornton, O Cracknell, T Ardron, T Habberfield.
Referee: Ben Whitehouse (WRU)
Rory McIlroy has had to join his European teammates in congratulating an American heckler who was challenged to make a putt during a Ryder Cup practice session – and won $100 from Justin Rose.
Team Europe’s Rose and McIlroy, plus Henrik Stenson and Andy Sullivan, were struggling to make the shot when a voice from the crowd shouted: “I could have made that!”
They invited the spectator to try, and Rose put a $100 bill on the line as added incentive. And, to roars of approval from the rest of the crowd, the heckler pulled off a perfect shot.
As he celebrated in style, even Team Europe had to give credit where it was due, laughing as they hugged the delighted fan.
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