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A black Audi is reportedly overturned at the scene of the Rhoose collision.
Residents report hearing a 'loud noise' at around ten to nine, and seeing a lollipop lady lying on the ground.
An Air Ambulance, which was at the scene, is understood to have just left.
Vale of Glamorgan MP Alun Cairns says he is 'liaising with police' following this morning's collision in Rhoose.
Police say children are among those injured.
– Alun Cairns MP
A terrible incident has taken place in Rhoose. My heart goes out to those affected. I am liaising with police over communication and support.
We can confirm that Wales Air Ambulance is on scene at an RTC in RhooseFrom @air_ambulance on Twitter:
Three rapid response vehicles and five emergency ambulances were sent to the scene, where there were "multiple casualties", a spokeswoman for Welsh Ambulance Services NHS Trust said.
She added the ambulance service was called to the single vehicle collision at about 8.55am this morning.
Road traffic collision Fontygary Road, Rhoose at 8.50am. Casualties taken to hospital. Road remains closed.From @swpcentral on Twitter:
X45 Service is not servicing Rhoose or Aberthaw due to a serious incident sorry for the inconvenience.From @estcoach on Twitter:
Service update - X91 - due to a serious RTC this will be redirected via B4265 not servicing Rhoose or Aberthaw sorry for the inconvenienceFrom @Cardiffbus on Twitter:
Police say the collision happened at around 8.50am
– South Wales Police
A car has overturned near Rhoose Primary School and there are a number of casualties – including adults and children.
The ages of those involved are not yet known. The road has been closed.
Traffic has returned to normal after the earlier accident on the M4 Malpas Straight Eastbound at J26 A4051 (Malpas Road).
This weekend the RNLI Lifeguards return to work at Pembrokeshire's beaches. Ahead of a busy summer ensuring the safety of beach goers, their efforts in the rescue of two surfers last June have been praised.
– Philip Davies, RNLI Lifeguard Manager
It's a pleasure to recognise the great work that the RNLI team were involved in at Newgale last year. RNLI lifeguards face all kinds of scenarios on the beach, and due to the intensive training they take part in throughout the season, they've got the skills and abilities to face anything and help those in trouble on the coast.'