Gethin Jenkins will captain Wales against RBS 6 Nations opponents Italy on Saturday after Sam Warburton was ruled out by a knee problem, the Welsh Rugby Union has announced.
Warburton did not play against Scotland last month because of a thigh injury that forced him off at half-time in Dublin the previous weekend.
Gatland has made one other change from the side that beat England at Twickenham 10 days ago, recalling fit-again hooker Matthew Rees instead of Ken Owens.
Former squad captain Matthew Rees makes a return as hooker, with Jamie Roberts making a rapid recovery from his half-time injury in last week's match to keep his place in the back line
A win would see Wales through to a final day decider against France and the possibility of a magnificent Grand Slam.
Gatland says he has no concerns about selecting Justin Tipuric to face Italy, reports Richard Morgan
WALES: Leigh Halfpenny; Alex Cuthbert, Jonathan Davies, Jamie Roberts, George North; Rhys Priestland, Michael Phillips; Gethin Jenkins (C), Matthew Rees, Adam Jones, Alun Wyn Jones, Ian Evans, Dan Lydiate, Justin Tipuric, Toby Faletau
REPLACEMENTS: Ken Owens, Paul James, Luke Charteris, Ryan Jones, Lloyd Williams, James Hook, Scott Williams