Scarlets duo Ken Owens and Scott Williams have been selected for Wales' first test against Australia in Brisbane this Saturday.
Owens replaces Matthew Rees at hooker, who started in Wales' win over the Barbarians last weekend. Williams, who scored the try that sealed the Triple Crown against England, replaces the injured Jamie Roberts.
In all Wales show four changes to the side that beat France 16-9 to lift the Grand Slam in March. Second rows Bradley Davies and Luke Charteris replace Ian Evans and Alun Wyn Jones, who moves to the bench.
There's also a place amongst the replacements for uncapped Ospreys centre Ashley Beck.
Caretaker coach Rob Howley says the team are prepared for the challenge ahead.
Wales face Australia on Saturday in the first of three Test matches.
Wales team: Leigh Halfpenny, Alex Cuthbert, Jonathan Davies, Scott Williams, George North; Rhys Priestland, Mike Phillips; Gethin Jenkins, Ken Owens, Adam Jones, Bradley Davies, Luke Charteris, Dan Lydiate, Sam Warburton (Captain), Toby Faletau
Replacements: Matthew Rees, Paul James, Alun Wyn Jones, Ryan Jones, Lloyd Williams, James Hook, Ashley Beck