Swiss airline Heveltic Air have announced that they are ending their winter flights from Cardiff Airport.
The 100-seat service, which operates via Bristol, ran three times a week last winter.
This year, the service will operate between Bristol and Zurich only.
The confirmation comes after figures released showed that Cardiff Airport suffered a six figure loss last year. The figures also showed the number of passengers also fell by 40 percent. Airport bosses said that legal requirements mean there are high fixed costs to running the airport.
Commenting on today's news, Shadow Minister for Transport Byron Davies AM, says it should act as a warning for the First Minister.
Helvetic’s chief financial officer, Tobias Pogorevc, said planning was under way for next year's summer schedule and the company was in discussion with "several tour operators" about planning packages out of Cardiff. A decision about the route will be made at the end of October.