Ryan Jones will remain captain despite Sam Warburton's return to the Wales squad to face Scotland on Saturday. Last season's Grand Slam winning captain replaces Justin Tipuric in Rob Howley's line up.
Jones, who has captained Wales a record 31 times, took over from Warburton when Wales beat France in Paris, and he unsurprisingly keeps the job this weekend.
In other changes, Bath forward Paul James will come in for Gethin Jenkins who is suffering from a calf muscle injury following the team's 26-9 victory over Italy in Rome 10 days ago.
Alun-Wyn Jones will also return to the team replacing Andrew Coombs.
Wales' interim head coach Rob Howley retains the same back division for a fourth successive game, but four changes on the bench from Rome see Cardiff Blues prop Scott Andrews come in for James and Ryan Bevington replace Craig Mitchell, with Coombs and Tipuric swapping places with Jones and Warburton respectively.
It will be Alun-Wyn Jones' first Test start since he suffered a shoulder injury against Argentina last November and subsequently underwent surgery.
It is a tough call on Newport Gwent Dragons forward Coombs, whose performances in the Six Nations so far have impressed, but Jones offers considerable experience, having won almost 70 caps.
Wales remain in contention to successfully defend the Six Nations title, although unbeaten England remain tournament favourites.